Rapid and consistent evolution of colistin resistance in Pseudomonas aeruginosa during morbidostat culture

نویسندگان

  • Bianca Regenbogen
  • Matthias Willmann
  • Matthias Steglich
  • Boyke Bunk
  • Ulrich Nübel
  • Silke Peter
  • Richard A. Neher
چکیده

Bianca Regenbogen1†∗, Matthias Willmann2,5∗, Matthias Steglich, Boyke Bunk, Ulrich Nübel, Silke Peter, Richard A. Neher Max Planck Institute for Developmental Biology, 72076 Tübingen, Germany. †present address: Institute of Plant Breeding, University of Hohenheim, Stuttgart, Germany. Institute for Medical Microbiology, University Hospital Tübingen, Germany. Leibniz Institute DSMZ, Braunschweig, Germany. German Center for Infection Research (DZIF), Braunschweig, Germany German Center for Infection Research (DZIF), partner site Tübingen, Germany ∗joint first authors.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Pattern of antibiotic resistance in nosocomial infections with Gram-negative bacilli in ICU patients (Tehran, Iran) during the years 2012-2014

Background and Objective: Owing to the new patterns of antibiotic resistance, selection of the appropriate antibiotics for the treatment of nosocomial infections, especially gram-negative bacilli, has become a big challenge. Therefore, the aim of this study was to evaluate the antibiotic resistance of nosocomial infections with Gram-negative bacilli in Iran during the years 2012-2014. Material...

متن کامل

Molecular epidemiology of colistin-resistant Pseudomonas aeruginosa producing NDM-1 from hospitalized patients in Iran

Objective(s): Resistance to carbapenems is the principal reason for the continuing utilization of colistin as a last resort choice for treating the infections resulted from multidrug carbapenem-resistant Pseudomonas aeruginosa (CRPA) isolates. The assessment of antimicrobial resistance pattern, the prevalence of carbapenem-resistance determinants, and molecular epidemiology of colistin-resistan...

متن کامل

Antimicrobial Resistance Profile of Pseudomonas Aeruginosa Strains

Abstract Background and Objectives: Pseudomonas aeruginosa is the most common organism, which is separated from the burn infections.  Due to increased antibiotic resistance, there are many problems to deal with the infections caused by Pseudomonas aeruginosa. This study aimed to determine the resistance to antibiotics against clinical isolates of Pseudomonas using phenotype me...

متن کامل

The evolution of antimicrobial peptide resistance in Pseudomonas aeruginosa is shaped by strong epistatic interactions

Colistin is an antimicrobial peptide that has become the only remaining alternative for the treatment of multidrug-resistant Gram-negative bacterial infections, but little is known of how clinical levels of colistin resistance evolve. We use in vitro experimental evolution and whole-genome sequencing of colistin-resistant Pseudomonas aeruginosa isolates from cystic fibrosis patients to reconstr...

متن کامل

Corrigendum: Evolved resistance to colistin and its loss due to genetic reversion in Pseudomonas aeruginosa

The increased reliance on colistin for treating multidrug-resistant Gram-negative bacterial infections has resulted in the emergence of colistin-resistant Pseudomonas aeruginosa. We attempted to identify genetic contributors to colistin resistance in vitro evolved isogenic colistin-resistant and -susceptible strains of two P. aeruginosa lineages (P5 and P155). Their evolutionary paths to acquis...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2016